Abstract:
:The metal-interaction of aurine tricarboxylic acid (ATA) and its inhibitory effect on the DNA binding of NFkappaB were studied. Chemical speciation and spectroscopic studies have shown the strong interaction of ATA with metal ions present in the biological systems. EPR, FTIR and electronic spectral studies indicated the square planar structure of the metal-binding carboxylic and hydroxyl groups of ATA indicating the ground state 2B1g. Electrophoretic mobility shift assay using NFkappaB and 32P labeled DNA has shown that ATA was inhibitory against the DNA-NFkappaB binding at 30 microM. This activity was the strongest among the metal-chelating inhibitors of NFkappaB-DNA binding reported so far.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Sharma RK,Garg BS,Kurosaki H,Goto M,Otsuka M,Yamamoto T,Inoue Jdoi
10.1016/s0968-0896(00)00109-7subject
Has Abstractpub_date
2000-07-01 00:00:00pages
1819-23issue
7eissn
0968-0896issn
1464-3391pii
S0968089600001097journal_volume
8pub_type
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