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Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines.

Abstract：

:A series of aryloxypropanolamines (5a-r) of different chalcones (3a-e) were synthesized and evaluated for antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models. Among them compounds 5a, g, m, o, p and r showed significant reduction in blood glucose levels in both SLM and STZ animal models.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Satyanarayana M,Tiwari P,Tripathi BK,Srivastava AK,Pratap R

doi

10.1016/j.bmc.2003.12.026

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

883-9

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968089604000033

journal_volume

12

pub_type

杂志文章

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