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Oligonucleotides containing a lysine residue as 3'-3' junction for alternate strand triple helix formation.

Abstract：

:Oligonucleotides with a 3'-3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Barone G,De Napoli L,Di Fabio G,Giancola C,Messere A,Montesarchio D,Petraccone L,Piccialli G

doi

10.1016/s0968-0896(01)00164-x

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

2895-900

issue

11

eissn

0968-0896

issn

1464-3391

pii

S096808960100164X

journal_volume

9

pub_type

杂志文章

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