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Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins.

Abstract：

:Compounds which inhibit the HIV-1 replication cycle have been found amongst fragment peptides derived from an HIV-1 matrix (MA) protein. Overlapping peptide libraries covering the whole sequence of MA were designed and constructed with the addition of an octa-arginyl group to increase their cell membrane permeability. Imaging experiments with fluorescent-labeled peptides demonstrated these peptides with an octa-arginyl group can penetrate cell membranes. The fusion of an octa-arginyl group was proven to be an efficient way to find active peptides in cells such as HIV-inhibitory peptides.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Narumi T,Komoriya M,Hashimoto C,Wu H,Nomura W,Suzuki S,Tanaka T,Chiba J,Yamamoto N,Murakami T,Tamamura H

doi

10.1016/j.bmc.2011.12.055

subject

Has Abstract

pub_date

2012-02-15 00:00:00

pages

1468-74

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(11)01073-X

journal_volume

20

pub_type

杂志文章

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