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Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid.

Abstract：

:When a neutral solution of thymidine and ascorbic acid was irradiated with UV light of wavelength longer than 300 nm in the presence of salicylic acid as a photosensitizer, six product peaks appeared in an HPLC chromatogram in addition to small amounts of thymidine dimers. The six products were identified as three pairs of diastereomers of 5-(2-deoxy-2-l-ascorbyl)-5,6-dihydrothymidine, 5-(2-l-ascorbyl)-5,6-dihydrothymidine, and 5,6-dihydrothymidine. These results suggest that novel DNA damage may be generated by ascorbic acid with salicylic acid induced by sunlight.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Suzuki T,Kishida Y

doi

10.1016/j.bmc.2019.115046

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

115046

issue

19

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(19)31142-3

journal_volume

27

pub_type

杂志文章

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