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DNA-binding peptides searched from the solid-phase combinatorial library with the use of the magnetic beads attaching the target duplex DNA.

Abstract：

:We have exhibited successful and rapid screening of DNA-binding peptide ligands from solid-phase library beads with the use of the target DNA-conjugated magnetic beads. The target duplex DNA (3) has a polyether linker between two complementary sequences (T4A3G-ether linker-CT3A4) and is stable in the duplex form during the selection procedure. Finally, 71 pentapeptide sequences were identified from the solid-phase pentapeptide library. From an analysis of the peptide sequences identified in this study, it has been revealed that peptide ligands contain hydrophobic amino acids as the major component. The synthetic peptides with identified sequences and a combination of the major components have exhibited moderate to high binding affinity to the duplex DNA in competition experiments with ethidium-DNA complexes.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Alam MR,Maeda M,Sasaki S

doi

10.1016/s0968-0896(99)00298-9

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

465-73

issue

2

eissn

0968-0896

issn

1464-3391

pii

S0968089699002989

journal_volume

8

pub_type

杂志文章

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