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Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds.

Abstract：

:Use of herbal plant remedies to treat infectious diseases is a common practice in many countries in traditional and alternative medicine. However to date there are only few antimicrobial agents derived from botanics. Based on microbiological screening tests of crude plant extracts we identified four compounds derived from Krameria, Aesculus hippocastanum and Chelidonium majus that showed a potentially interesting antimicrobial activity. In this work we present an in depth characterization of the inhibition activity of these pure compounds on the formation of biofilm of Staphylococcus aureus as well as of Staphylococcus epidermidis strains. We show that two of these compounds possess interesting potential to become active principles of new drugs.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Artini M,Papa R,Barbato G,Scoarughi GL,Cellini A,Morazzoni P,Bombardelli E,Selan L

doi

10.1016/j.bmc.2011.11.052

subject

Has Abstract

pub_date

2012-01-15 00:00:00

pages

920-6

issue

2

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(11)00988-6

journal_volume

20

pub_type

杂志文章

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