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Structural advantage of dendritic poly(L-lysine) for gene delivery into cells.

Abstract：

:This study aimed to investigate the relationships between structures of gene carrier molecules and their activities for gene delivery into cells. We compared 2 types of poly(L-lysine) as carriers, that is, dendritic poly(L-lysine) (KG6) and linear poly(L-lysine) (PLL). KG6 formed a neutral DNA complex, and its DNA compaction level was weaker than that of PLL. The amount of DNA binding and uptake into cells mediated by PLL was 4-fold higher than that with KG6. However, KG6-mediated gene expression was 100-fold higher than that by PLL. Since pK(a) values of terminal amines of KG6 were lowered even though small amounts of DNA were internalized into cells, sufficient DNA amounts for effective gene expression escaped to the cytosol due to the proton sponge effect in the endosome. In addition, weakly compacted DNA with KG6 was advantageous in accessing RNA polymerase in the cell nucleus. On the other hand, PLL did not show the proton sponge effect in the endosome and resulted in strong compaction of DNA. Even though large DNA amounts were internalized into cells, most of the DNA would not take part in gene expression systems in the nucleus. Amount of induced cytokine production after intravenous injection of DNA complexes with KG6 and PLL was low, and was similar to the case when DNA was injected alone. Therefore, no significant difference in effects on cytokine production was observed between KG6 and PLL.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Yamagata M,Kawano T,Shiba K,Mori T,Katayama Y,Niidome T

doi

10.1016/j.bmc.2006.09.033

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

526-32

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00764-4

journal_volume

15

pub_type

杂志文章

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