Abstract:
:A series of L-arginine derivatives were designed, synthesized and assayed for their activities against amino-peptidase N (APN)/CD13 and metalloproteinase-2 (MMP-2). The results showed that most compounds exhibited high inhibitory activities against APN and low activities against MMP-2. Within this series, two compounds 5q and 5s (IC(50)=5.3 and 5.1 microM) showed similar inhibitory activities compared with bestatin (IC(50)=3.8 microM), which could be used as novel lead compounds for the future APN inhibitors development as anticancer agents.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Mou J,Fang H,Jing F,Wang Q,Liu Y,Zhu H,Shang L,Wang X,Xu Wdoi
10.1016/j.bmc.2009.04.056subject
Has Abstractpub_date
2009-07-01 00:00:00pages
4666-73issue
13eissn
0968-0896issn
1464-3391pii
S0968-0896(09)00414-3journal_volume
17pub_type
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