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An efficient asymmetric synthesis of (S)-atenolol: using hydrolytic kinetic resolution.

Abstract：

:Enantiomerically pure (S)-atenolol was prepared by using (R,R) salen Co(III) complex for the resolution of terminal epoxide. This process was carried out at room temperature in excellent enantio selectivity. The method can be applied for large-scale preparation of (S)-atenolol without any problem.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Bose DS,Venkat Narsaiah A

doi

10.1016/j.bmc.2004.10.057

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

627-30

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(04)00860-0

journal_volume

13

pub_type

杂志文章

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