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Carbonic anhydrases of anaerobic microbes.

Abstract：

:Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to bicarbonate and are abundantly distributed in prokaryotes and eukaryotes. There are five classes (α,β,γ,δ,ζ) with no significant sequence or structural identity among them, a remarkable example of convergent evolution. The β and γ classes predominate in anaerobic microbes, living without O2, that comprise a substantial portion of the living protoplasm on Earth. Anaerobes reside in the lower intestinal tract of humans, one of many O2-free environments on Earth, where they convert complex biomass to methane and CO2 contributing an essential link in the global carbon cycle. Carbon dioxide is a universal metabolite of anaerobes necessitating CA for a diversity of proposed functions.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Ferry JG

doi

10.1016/j.bmc.2012.12.005

subject

Has Abstract

pub_date

2013-03-15 00:00:00

pages

1392-5

issue

6

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(12)00966-2

journal_volume

21

pub_type

杂志文章

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