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ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template.

Abstract：

:The synthesis and structure-activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERbeta selectivity on the order of 20-70-fold.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Edsall RJ Jr,Harris HA,Manas ES,Mewshaw RE

doi

10.1016/s0968-0896(03)00303-1

subject

Has Abstract

pub_date

2003-08-05 00:00:00

pages

3457-74

issue

16

eissn

0968-0896

issn

1464-3391

pii

S0968089603003031

journal_volume

11

pub_type

杂志文章

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