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DNA analogues: from supramolecular principles to biological properties.

Abstract：

:Mainly driven by the needs of antisense research, a large number of oligonucleotide analogues have been prepared and evaluated over the last 15 years. Besides minor structural modifications of the building blocks of DNA and RNA itself, a considerable effort has been devoted to the de novo design of nucleoside analogues with improved binding properties. A particularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Leumann CJ

doi

10.1016/s0968-0896(01)00348-0

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

841-54

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968089601003480

journal_volume

10

pub_type

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