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3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication.

Abstract：

:A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Iannazzo D,Piperno A,Romeo G,Romeo R,Chiacchio U,Rescifina A,Balestrieri E,Macchi B,Mastino A,Cortese R

doi

10.1016/j.bmc.2008.09.006

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

9610-5

issue

21

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00827-4

journal_volume

16

pub_type

杂志文章

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