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Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes.

Abstract：

:This study measured the antiplasmodial activity of nine zinc-dipicolylamine (ZnDPA) complexes against three strains of Plasmodium falciparum, the causative parasite of malaria. Growth inhibition assays showed significant activity against all tested strains, with 50% inhibitory concentrations between 5 and 600nM and almost no toxic effect against host cells including healthy red blood cells. Fluorescence microscopy studies with a green-fluorescent ZnDPA probe showed selective targeting of infected red blood cells. The results suggest that ZnDPA coordination complexes are promising antiplasmodial agents with potential for targeted malaria treatment.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Rice DR,de Lourdes Betancourt Mendiola M,Murillo-Solano C,Checkley LA,Ferdig MT,Pizarro JC,Smith BD

doi

10.1016/j.bmc.2017.03.050

subject

Has Abstract

pub_date

2017-05-15 00:00:00

pages

2754-2760

issue

10

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(17)30295-X

journal_volume

25

pub_type

杂志文章

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