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Pharmacodynamics and pharmacokinetics studies of phenoxazinium derivatives for antimalarial agent.

Abstract：

:In vivo antimalarial drug candidates screening test was carried out on a series of water-soluble 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. Among them, 3-(diethylamino)-7-(piperidin-1-yl)phenoxazin-5-ium chloride (SSJ-206) showing highest efficacy was chosen for further pharmcodynamics and pharmacokinetics study. It was supported from these data that the phenoxazinium salts, SSJ-206, would be one of hopeful candidates as an oral antimalarial drug.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Yang M,Ge JF,Arai C,Itoh I,Fu Q,Ihara M

doi

10.1016/j.bmc.2009.01.021

subject

Has Abstract

pub_date

2009-02-15 00:00:00

pages

1481-5

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00052-2

journal_volume

17

pub_type

杂志文章

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