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Modulation of remote DNA oxidation by hybridization with peptide nucleic acids (PNA).

Abstract：

:We have examined the efficiency of DNA photooxidation in DNA/PNA duplex and DNA/(PNA)(2) triplex for the first time. DNA/PNA duplex was cleaved at GG steps by external riboflavin with high efficiency like specific GG cleavage in DNA/DNA duplex. However, the 5'G selectivity of the GG oxidation in DNA/PNA duplex was much lower than that observed in DNA/DNA duplex. Remote DNA oxidation of oxidant-tethered DNA/PNA duplex was considerably suppressed. In contrast, the formation of DNA/(PNA)(2) triplex by hybridization with two PNA strands completely inhibited the remote GG oxidation, indicating that PNA acts as an inhibition for remote oxidative DNA damage.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Okamoto A,Tanabe K,Dohno C,Saito I

doi

10.1016/s0968-0896(01)00320-0

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

713-8

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968089601003200

journal_volume

10

pub_type

杂志文章

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