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Antitumor activity and COMPARE analysis of bis-indole derivatives.

Abstract：

:This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure-activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Andreani A,Burnelli S,Granaiola M,Leoni A,Locatelli A,Morigi R,Rambaldi M,Varoli L,Landi L,Prata C,Dalla Sega FV,Caliceti C,Shoemaker RH

doi

10.1016/j.bmc.2010.03.063

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

3004-11

issue

9

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00277-4

journal_volume

18

pub_type

杂志文章

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