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Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus.

Abstract：

:A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50<0.41 microM and SI>81.2, was the most promising compound and selected as the benchmark compound for further optimization.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Luo Y,Yao JP,Yang L,Feng CL,Tang W,Wang GF,Zuo JP,Lu W

doi

10.1016/j.bmc.2010.05.076

subject

Has Abstract

pub_date

2010-07-15 00:00:00

pages

5048-55

issue

14

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00515-8

journal_volume

18

pub_type

杂志文章

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