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Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK.

Abstract：

:Bacterial enoyl-acyl carrier protein (ACP) reductases (FabI and FabK) catalyze the final step in each cycle of bacterial fatty acid biosynthesis and are attractive targets for the development of new antibacterial agents. Here, we report the development of novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae. Based on structure-activity relationship (SAR) studies of our screening hits, we have developed novel phenylimidazole derivatives as potent FabK inhibitors.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Ozawa T,Kitagawa H,Yamamoto Y,Takahata S,Iida M,Osaki Y,Yamada K

doi

10.1016/j.bmc.2007.08.050

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

7325-36

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00720-1

journal_volume

15

pub_type

杂志文章

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