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CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors.

Abstract：

:Several derivatives out of a series of antifungal agents exhibited a good inhibitory potency against aromatase as well as a fairly good selectivity toward CYP17, even if lacking H-bond accepting substituents. Their common structural feature is a flexible backbone that did not fit into previously reported CYP19 models. Thus, a ligand-based approach was exploited to develop a novel statistically robust, self-consistent and predictive 3D-QSAR model herein proposed as a helpful tool to design new aromatase inhibitors.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Castellano S,Stefancich G,Ragno R,Schewe K,Santoriello M,Caroli A,Hartmann RW,Sbardella G

doi

10.1016/j.bmc.2008.08.046

subject

Has Abstract

pub_date

2008-09-15 00:00:00

pages

8349-58

issue

18

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00776-1

journal_volume

16

pub_type

杂志文章

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