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Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells.

Abstract：

:Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4(+) T cells, is an important stimulus for the switch of the antibody isotype to IgE in both mice and humans. In this study we investigated the inhibitory activity of IL-4 production in activated T cells by screening ceramide derivatives prepared by solid phase combinatorial chemistry. Many ceramide derivatives significantly inhibited IL-4 production in T cells. In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Park J,Li Q,Chang YT,Kim TS

doi

10.1016/j.bmc.2005.01.027

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

2589-95

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(05)00053-2

journal_volume

13

pub_type

杂志文章

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