Abstract：
:Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF).
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Ancizu S,Moreno E,Solano B,Villar R,Burguete A,Torres E,Pérez-Silanes S,Aldana I,Monge Adoi
10.1016/j.bmc.2010.02.024subject
Has Abstractpub_date
2010-04-01 00:00:00pages
2713-9issue
7eissn
0968-0896issn
1464-3391pii
S0968-0896(10)00145-8journal_volume
18pub_type
杂志文章abstract：:Due to the global threat of antibiotic resistance mediated by New Delhi metallo-beta-lactamase-1 (NDM-1) and the lack of structurally diverse inhibitors reported for this enzyme, we developed screening and counter-screening assays for manual and automated formats. The manual assay is a trans-well absorbance-based endp...
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更新日期：2007-11-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
doi：10.1016/j.bmc.2007.10.048
更新日期：2008-01-15 00:00:00
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doi：10.1016/j.bmc.2009.05.042
更新日期：2009-07-15 00:00:00
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更新日期：1999-05-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章,评审
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更新日期：2009-08-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
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更新日期：2004-09-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2005-01-03 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
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更新日期：2008-12-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
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更新日期：2008-09-01 00:00:00
