Abstract：
:A phytochemical analysis of Aster sedifolius has led to the isolation of three novel triterpenoid saponins, based on an oleane-type skeleton and named astersedifolioside A (1), B (2) and C (3). On the basis of chemical, and 2D NMR and mass spectrometry data, the structures of the new compounds were elucidated as 3-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside] (1), 3-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (1-->4)-O-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside] (2) and 3-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (1-->4)-O-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside] (3). The isolated compounds showed antiproliferative effect in KiMol, a transformed thyroid cell line.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Corea G,Iorizzi M,Lanzotti V,Cammareri M,Conicella C,Laezza C,Bifulco Mdoi
10.1016/j.bmc.2004.06.042subject
Has Abstractpub_date
2004-09-15 00:00:00pages
4909-15issue
18eissn
0968-0896issn
1464-3391pii
S0968-0896(04)00487-0journal_volume
12pub_type
杂志文章abstract：:4-{[2-[(2-Furylsulfonyl)(isobutyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoic acid analogs 2a and b and a series of the acid analogs, in which the carboxylic acid residue of 2b was replaced with various kinds of carboxylic acid bioisosteres, were synthesized and evaluated as EP1 receptor antagonists. Compound 2b ...
journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
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doi：10.1016/j.bmc.2006.08.008
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journal_title：Bioorganic & medicinal chemistry
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doi：10.1016/s0968-0896(02)00463-7
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journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章,评审
doi：10.1016/j.bmc.2008.12.061
更新日期：2009-06-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
doi：10.1016/s0968-0896(01)00202-4
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journal_title：Bioorganic & medicinal chemistry
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更新日期：1994-01-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
doi：10.1016/j.bmc.2010.03.070
更新日期：2010-05-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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doi：10.1016/s0968-0896(01)00140-7
更新日期：2001-09-01 00:00:00
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doi：10.1016/j.bmc.2007.06.054
更新日期：2007-10-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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doi：10.1016/j.bmc.2007.05.052
更新日期：2007-08-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2014-12-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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doi：10.1016/j.bmc.2003.08.008
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journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2014-12-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
doi：10.1016/0968-0896(95)00080-z
更新日期：1995-07-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
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更新日期：1994-07-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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doi：10.1016/j.bmc.2007.07.026
更新日期：2007-11-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
doi：10.1016/j.bmc.2012.06.038
更新日期：2012-09-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2002-06-01 00:00:00
