当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY期刊下所有文献 > Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Abstract：

:Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Woo YH,Fernandes RP,Proteau PJ

doi

10.1016/j.bmc.2005.11.012

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

2375-85

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(05)01076-X

journal_volume

14

pub_type

杂志文章

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