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A novel fluorescent probe based on naphthalimide for imaging nitroreductase (NTR) in bacteria and cells.

Abstract：

:A nitroreductase (NTR) responsive fluorescent probe, Na-NO2, comprising p-nitrobenzyl as the unique recognition group and 1,8-naphthalimide as fluorophore, was synthesized. Na-NO2 showed remarkable fluorescence "turn-on" signal in the presence of NTR under DMSO/H2O (1:19, v/v) buffered with PBS (pH = 7) solution in the presence of NADH (300 µM). Furthermore, the probe has a low detection limit down to 3.4 ng/mL and it is very sensitive towards the NTR in Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), normal and tumor cells such as HL-7702, HepG-2 and MCF-7.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Zhang Z,Lv T,Tao B,Wen Z,Xu Y,Li H,Liu F,Sun S

doi

10.1016/j.bmc.2019.115280

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

115280

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(19)31461-0

journal_volume

28

pub_type

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