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Enzyme-catalysed enantioselective hydrolysis of racemic naproxen nitrile.

Abstract：

:The bacterial strain Rhodococcus butanica (ATCC 21197), which exhibits nitrilase and nitrile hydratase/amidase activities, catalyses the enantioselective hydrolysis of racemic naproxen nitrile (R/S)-1 to furnish a moderate enantiomeric excess of (S)-naproxen (S)-3. Racemic naproxen amide (R/S)-2 is not a good substrate for this strain. Resting cells of the newly selected bacterial strain Rhodococcus sp. C3II catalyse the enantioselective hydrolyses of racemic naproxen nitrile (R/S)-1 and naproxen amide (R/S)-2 as well, to give (S)-3 in excellent optical (99% e.e.) and good chemical yields in aqueous medium and in the biphasic system of phosphate buffer/hexane.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Effenberger F,Böhme J

doi

10.1016/0968-0896(94)85022-4

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

715-21

issue

7

eissn

0968-0896

issn

1464-3391

pii

0968-0896(94)85022-4

journal_volume

2

pub_type

杂志文章

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