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Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole.

Abstract：

:G-quadruplexes (G4s) are non-B DNA structures present in guanine-rich regions of gene regulatory areas, promoters and CpG islands, but their occurrence and functions remain incompletely understood. Thus, methodology to identify G4 sequences is needed. Here, we describe the synthesis of a novel cyclic hepta-oxazole compound, L1Bio-7OTD (1), bearing a biotin affinity-tag as a tool to pull down G4 structures from mixtures of G4-forming and non G4-forming DNA sequences. We confirmed that it could pull down G4s associated with telomeres, bcl-2 gene, and c-kit gene.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Iida K,Tsushima Y,Ma Y,Sedghi Masoud S,Sakuma M,Yokoyama T,Yoshida W,Ikebukuro K,Nagasawa K

doi

10.1016/j.bmc.2019.02.056

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

1742-1746

issue

8

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(18)32132-1

journal_volume

27

pub_type

杂志文章

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