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New furanoflavanoids, intestinal alpha-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.).

Abstract：

:A bioassay-guided fractionation and chemical examination of antihyperglycemic root extract of Derris indica resulted in isolation and characterization of two new furanoflavanoids (1, 2) along with thirteen known compounds (3-15). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested in vitro for intestinal alpha-glucosidase inhibitory and DPPH radical activity. New compounds (1, 2) displayed moderate intestinal alpha-glucosidase inhibitory as well as free radical scavenging activity. Other compounds also displayed varying degrees of moderate intestinal alpha-glucosidase inhibitory activity. Pongamol (6) displayed potent intestinal alpha-glucosidase inhibition.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Ranga Rao R,Tiwari AK,Prabhakar Reddy P,Suresh Babu K,Ali AZ,Madhusudana K,Madhusudana Rao J

doi

10.1016/j.bmc.2009.05.051

subject

Has Abstract

pub_date

2009-07-15 00:00:00

pages

5170-5

issue

14

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00503-3

journal_volume

17

pub_type

杂志文章

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