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Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

Abstract：

:The synthesis of several 6,7,8,9,10,11-hexahydro-9-methyl-5,7:9,11-dimethano-5H-benzocyclononen-7-amines is reported. Several of them display low micromolar NMDA receptor antagonist and/or trypanocidal activities. Two compounds are endowed with micromolar anti vesicular stomatitis virus activity, while only one compound shows micromolar anti-influenza activity. The anti-influenza activity of this compound does not seem to be mediated by blocking of the M2 protein.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Torres E,Duque MD,López-Querol M,Taylor MC,Naesens L,Ma C,Pinto LH,Sureda FX,Kelly JM,Vázquez S

doi

10.1016/j.bmc.2011.11.050

subject

Has Abstract

pub_date

2012-01-15 00:00:00

pages

942-8

issue

2

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(11)00986-2

journal_volume

20

pub_type

杂志文章

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