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DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases.

Abstract：

:C1027 is a potent antitumor agent that damages DNA. It has the unusual ability to produce double strand breaks and interstrand cross-links (ICLs) intracellularly, which enable it to initiate concurrent ataxia-telangiestasia mutated (ATM) and Rad-3 related (ATR) independent damage responses. The latter form of damage is not well characterized. We have examined the effect of DNA sequence on C1027 reactivity and found it to be more diverse than previously thought. In addition, analysis of the chemical stability of ICLs suggests that they result from reaction with the deoxyribose ring on one strand but direct addition to a nucleobase on the opposite strand.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

San Pedro JM,Beerman TA,Greenberg MM

doi

10.1016/j.bmc.2012.06.004

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

4744-50

issue

15

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(12)00470-1

journal_volume

20

pub_type

杂志文章

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