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Probing linker design in citric acid-ciprofloxacin conjugates.

Abstract：

:A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Milner SJ,Snelling AM,Kerr KG,Abd-El-Aziz A,Thomas GH,Hubbard RE,Routledge A,Duhme-Klair AK

doi

10.1016/j.bmc.2014.04.009

subject

Has Abstract

pub_date

2014-08-15 00:00:00

pages

4499-505

issue

16

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(14)00253-3

journal_volume

22

pub_type

杂志文章

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