Abstract：
:The action of the coumarin-type drugs and related compounds is reviewed to their VKOR antagonistic effects. In our study, twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement of PIVKA-II levels) anticoagulant study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Abdelhafez OM,Amin KM,Batran RZ,Maher TJ,Nada SA,Sethumadhavan Sdoi
10.1016/j.bmc.2010.04.009subject
Has Abstractpub_date
2010-05-15 00:00:00pages
3371-8issue
10eissn
0968-0896issn
1464-3391pii
S0968-0896(10)00313-5journal_volume
18pub_type
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