Abstract：
:Twenty-four compounds of 4-methoxy-N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] benzene sulfonamides and N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] naphthyl sulfonamides were prepared and evaluated as 5-HT(7) receptor antagonists. Most of the compounds showed the IC(50) values of 12-580nM. Four methyl branched analogues were also obtained, but the activity for methyl branched analogues was almost same as its straight chain congeners. Among the synthesized compounds, 3c showed a good activity on 5-HT(7) receptors and a good selectivity on 5-HT(1a), 5-HT(2a), 5-HT(2c), and 5-HT(6) receptors.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Yoon J,Yoo EA,Kim JY,Pae AN,Rhim H,Park WK,Kong JY,Park Choo HYdoi
10.1016/j.bmc.2008.04.023subject
Has Abstractpub_date
2008-05-15 00:00:00pages
5405-12issue
10eissn
0968-0896issn
1464-3391pii
S0968-0896(08)00351-9journal_volume
16pub_type
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