Abstract:
:Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Duveau DY,Arce PM,Schoenfeld RA,Raghav N,Cortopassi GA,Hecht SMdoi
10.1016/j.bmc.2010.06.104subject
Has Abstractpub_date
2010-09-01 00:00:00pages
6429-41issue
17eissn
0968-0896issn
1464-3391pii
S0968-0896(10)00632-2journal_volume
18pub_type
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