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Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum.

Abstract：

:Two novel C(27)N(3)-type Lycopodium alkaloids, cryptadines A (1) and B (2) consisting of two octahydroquinoline rings (C(11)N) and a piperidine ring (C(5)N), have been isolated from the club moss Lycopodium cryptomerinum, and their structures and relative stereochemistry were elucidated on the basis of spectroscopic data, chemical transformations, and computational methods. Cryptadines A (1) and B (2) exhibited an inhibitory activity against acetylcholinesterase.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Koyama K,Hirasawa Y,Kobayashi J,Morita H

doi

10.1016/j.bmc.2007.08.043

subject

Has Abstract

pub_date

2007-12-15 00:00:00

pages

7803-8

issue

24

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00746-8

journal_volume

15

pub_type

杂志文章

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