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Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities.

Abstract：

:Twenty-seven natural product-like polyprenylated phenols and quinones were synthesized and their neuroprotective activity was tested using human monoamine oxidase B (MAO-B) and SH-SY5Y cells. Eight compounds inhibited MAO-B (IC50 values < 25 μM) and the inhibition mode and molecular docking of two (8c and 16c) were investigated. Compounds inhibiting MAO-B activity were additionally tested for their ability to protect SH-SY5Y cells from peroxide injury. Three derivatives (3c, 8c and 16c) exhibited both MAO-B inhibitory and neuroprotective activity. A structure activity-relationship study showed that a phenolic hydroxyl group and a longer side chain are important for both activities.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Kamauchi H,Oda T,Horiuchi K,Takao K,Sugita Y

doi

10.1016/j.bmc.2019.115156

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

115156

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(19)31230-1

journal_volume

28

pub_type

杂志文章

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