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An efficient substitution reaction for the preparation of thyroid hormone analogues.

Abstract：

:The substitution of the sterically hindered carbon of the potent thyroid hormone agonist, GC-1, was effected by a reaction based on the solvolysis of the benzylic hydroxyl group. The reaction was found to proceed in high yield with a variety of nucleophiles including alcohols, thiols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone analogues.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Yoshihara HA,Chiellini G,Mitchison TJ,Scanlan TS

doi

10.1016/s0968-0896(98)00085-6

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

1179-83

issue

8

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(98)00085-6

journal_volume

6

pub_type

杂志文章

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