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Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.

Abstract：

:Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assay expressing mutant G93A SOD1, two bioactive chemical hit compounds (1 and 2), identified as arylsulfanyl pyrazolones, were identified. The structural optimization of this scaffold led to the generation of a more potent analogue (19) with an EC(50) of 170nM. To determine the suitability of this class of compounds for further optimization, 1 was subjected to a battery of pharmacokinetic assays; most of the properties of 1 were good for a screening hit, except it had a relatively rapid clearance and short microsomal half-life stability. Compound 2 was found to be blood-brain barrier penetrating with a brain/plasma ratio=0.19. The optimization of this class of compounds could produce novel therapeutic candidates for ALS patients.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Chen T,Benmohamed R,Arvanites AC,Ralay Ranaivo H,Morimoto RI,Ferrante RJ,Watterson DM,Kirsch DR,Silverman RB

doi

10.1016/j.bmc.2010.10.052

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

613-22

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00988-0

journal_volume

19

pub_type

杂志文章

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