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Pleuromutilins. Part 1. The identification of novel mutilin 14-carbamates.

Abstract：

:A novel series of mutilin 14-carbamates has been discovered as a result of structure-activity studies on the naturally occurring antibiotic pleuromutilin (1). In particular, the 4-methoxybenzoylcarbamate, SB-222734 (15o) displays potent antibacterial activity against a number of bacterial pathogens which are resistant to currently used agents and shows enhanced metabolic stability when compared to earlier pleuromutilin derivatives. Such derivatives therefore have the potential to provide a new class of antibacterial agents for human therapy which address the threat of bacterial resistance.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Brooks G,Burgess W,Colthurst D,Hinks JD,Hunt E,Pearson MJ,Shea B,Takle AK,Wilson JM,Woodnutt G

doi

10.1016/s0968-0896(00)00338-2

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

1221-31

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968089600003382

journal_volume

9

pub_type

杂志文章

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