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Synthesis and anti-oomycete activity of novel quinazolin- and benzothiazol-6-yloxyacetamides: Potent aza-analogs and five-ring analogs of quinoline fungicides.

Abstract：

:Novel quinazolin- and benzothiazol-6-yloxyacetamides show excellent in vivo activity against the three economically most important Oomycete pathogens Phytophthora infestans, Plasmopara viticola and Pythium ultimum. They are polar analogs of known quinolin-6-yloxyacetamides, which are not active against the soil-borne damping-off disease caused by Pythium ultimum. The Bogert quinazoline synthesis, an almost forgotten heterocyclization technique, proved to be highly useful for the concise construction of required quinazolin-6-ol building blocks.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Beaudegnies R,Quaranta L,Murphy Kessabi F,Lamberth C,Knauf-Beiter G,Fraser T

doi

10.1016/j.bmc.2015.08.009

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

444-52

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(15)00676-8

journal_volume

24

pub_type

杂志文章

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