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Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Abstract：

:The synthesis of new meridianin derivatives substituted at the C-5 position of the 2-aminopyrimidine ring by various aryl groups and substituted or not by a methyl group on the indole nitrogen is described. These compounds were tested for their kinase inhibitory potencies toward five kinases (CDK5/p25, CK1delta/epsilon, GSK-3alpha/beta, Dyrk1A and Erk2) as well as their in vitro antiproliferative activities toward a human fibroblast primary culture and two human solid cancer cell lines (MCF-7 and PA 1).

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Akue-Gedu R,Debiton E,Ferandin Y,Meijer L,Prudhomme M,Anizon F,Moreau P

doi

10.1016/j.bmc.2009.05.017

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

4420-4

issue

13

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00460-X

journal_volume

17

pub_type

杂志文章

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