Abstract:
:2'-O-(2-Methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine phosphoramidite (MEPU) has been synthesized from d-ribose and 5-iodouracil and incorporated into triplex-forming oligonucleotides (TFOs) by automated solid-phase oligonucleotide synthesis. The TFOs gave very high triplex stability with their target duplexes as measured by ultraviolet/fluorescence melting and DNase I footprinting. The incorporation of MEPU into TFOs renders them resistant to degradation by serum nucleases.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Lou C,Xiao Q,Brennan L,Light ME,Vergara-Irigaray N,Atkinson EM,Holden-Dye LM,Fox KR,Brown Tdoi
10.1016/j.bmc.2010.07.005subject
Has Abstractpub_date
2010-09-01 00:00:00pages
6389-97issue
17eissn
0968-0896issn
1464-3391pii
S0968-0896(10)00648-6journal_volume
18pub_type
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