Abstract:
:Natural product inspired compound collections are prevalidated due to the evolutionary selection of the natural product scaffolds. Their synthesis requires the development of novel strategies amenable to formats suitable for library build-up. We describe a method for the synthesis of an oxepane library inspired by the core structure of oxepane natural products endowed with multiple bioactivities. Core aspects of the strategy are the establishment of a one-pot method employing different immobilized scavengers, the employment of an enyne ring closing reaction and diversification by means of different transformations, for example, cycloadditions and cross-metathesis reactions. In total, a collection of 115 oxepanes was obtained in 5-6-step reaction sequences.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Basu S,Waldmann Hdoi
10.1016/j.bmc.2014.05.039subject
Has Abstractpub_date
2014-08-15 00:00:00pages
4430-44issue
16eissn
0968-0896issn
1464-3391pii
S0968-0896(14)00388-5journal_volume
22pub_type
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