Abstract:
:Solid-phase synthesis of a small combinatorial library of dihydroceramide analogues as mixtures of erythro and threo diastereomers is described. Some dihydroceramide analogues cause growth arrest and apoptosis in a dose-dependent manner in human alveolar epithelial cells. This activity is likely due to the threo isomers, as evidenced by cellular studies with a pair of diastereomerically pure N-acyldihydrosphingosines. The apoptotic activity reported in this work provides information for the design of new compounds that may provide the basis for the generation of biochemical tools for the study of different pathologies where ceramide and/or dihydroceramide are involved.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Villorbina G,Canals D,Carde L,Grijalvo S,Pascual R,Rabal O,Teixidó J,Fabriàs G,Llebaria A,Casas J,Delgado Adoi
10.1016/j.bmc.2006.10.024subject
Has Abstractpub_date
2007-01-01 00:00:00pages
50-62issue
1eissn
0968-0896issn
1464-3391pii
S0968-0896(06)00829-7journal_volume
15pub_type
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