当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY期刊下所有文献 > Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.

Abstract：

:A new series of 2-thioether-benzothiazoles has been synthesized and evaluated for JNK inhibition. The SAR studies led to the discovery of potent, allosteric JNK inhibitors with selectivity against p38.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

De SK,Chen LH,Stebbins JL,Machleidt T,Riel-Mehan M,Dahl R,Chen V,Yuan H,Barile E,Emdadi A,Murphy R,Pellecchia M

doi

10.1016/j.bmc.2009.02.046

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

2712-7

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00198-9

journal_volume

17

pub_type

杂志文章

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