Abstract:
:Zinc mononuclear complexes with the second-generation quinolone antibacterial drug enrofloxacin in the absence or presence of a nitrogen donor heterocyclic ligand 1,10-phenanthroline or 2,2'-bipyridine have been synthesized and characterized. Enrofloxacin is on deprotonated mode acting as a bidentate ligand coordinated to zinc ion through the ketone and a carboxylato oxygen atoms. The crystal structure of bis(enrofloxacinato)(1,10-phenanthroline)zinc(II), 2, has been determined by X-ray crystallography. The biological activity of the complexes has been evaluated by examining their ability to bind to calf-thymus DNA (CT DNA) with UV and fluorescence spectroscopies. UV studies of the interaction of the complexes with DNA have shown that they can bind to CT DNA and the DNA binding constants have been calculated. Competitive studies with ethidium bromide (EB) have shown that the complexes exhibit the ability to displace the DNA-bound EB indicating that they bind to DNA in strong competition with EB for the intercalative binding site. The complexes exhibit good binding propensity to human and bovine serum albumin proteins having relatively high binding constant values.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Tarushi A,Raptopoulou CP,Psycharis V,Terzis A,Psomas G,Kessissoglou DPdoi
10.1016/j.bmc.2010.02.021subject
Has Abstractpub_date
2010-04-01 00:00:00pages
2678-85issue
7eissn
0968-0896issn
1464-3391pii
S0968-0896(10)00142-2journal_volume
18pub_type
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