The conformation and activity relationship of fused analogs of DuP753.

Abstract:

:We have prepared three conformationally restricted analogs of DuP753 in which one of the phenyl rings in the biphenyl moiety is fused to the imidazole ring, and have investigated the conformation-biological activity relationship of these compounds. Conformational analysis on DuP753 and these compounds confirms that a specific 3-dimensional arrangement of pharmacophoric elements is essential for biological activity.

journal_name

Bioorg Med Chem

authors

Yoo SE,Shin YA,Lee SH,Kim NJ

doi

10.1016/0968-0896(95)00002-x

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

289-95

issue

3

eissn

0968-0896

issn

1464-3391

pii

096808969500002X

journal_volume

3

pub_type

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