New synthesis of (+/-)-alpha-CMBHC and its confirmation as a metabolite of alpha-tocopherol (vitamin E).

Abstract:

:There is currently interest in the metabolism of the various compounds which make up the vitamin E family, especially with regards to the possible use of vitamin E metabolites as markers of oxidative stress and adequate vitamin E supply. A number of vitamin E metabolites have been described to date and we have recently developed a method to extract and quantitate a range of vitamin E metabolites in human urine. During the development of this method a new metabolite of alpha-tocopherol was identified, which we tentatively characterised as 5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid (alpha-CMBHC).(1) Here we describe the synthesis of alpha-CMBHC as a standard and confirm that it is a metabolite of alpha-tocopherol.

journal_name

Bioorg Med Chem

authors

Pope SA,Burtin GE,Clayton PT,Madge DJ,Muller DP

doi

10.1016/s0968-0896(01)00010-4

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

1337-43

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968089601000104

journal_volume

9

pub_type

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