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Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors.

Abstract：

:The synthesis of a series of 2,4-disubstituted morpholines is described and their affinities at human dopamine receptors reported. The orally bioavailable 7-azaindole compound 11 has nanomolar affinity at the hD4 receptor with > 1000-fold selectivity over the hD2 receptor.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Showell GA,Emms F,Marwood R,O'Connor D,Patel S,Leeson PD

doi

10.1016/s0968-0896(97)00176-4

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

1-8

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968089697001764

journal_volume

6

pub_type

杂志文章

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